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− | <br /> | + | <br />In each species, there have been no adverse effects on final mean body weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions had been observed. In another study, rats were uncovered to zero or 0. No thyroid hormone measurements were performed.<br /><br /><h3></h3><br />Furthermore, chronic research with fish and Daphnia have been carried out. For the toxicity to aquatic vegetation, no guideline research is on the market. However, considering the available research for toxicity to aquatic plants, the NOEC for algae could be assumed to be greater than that for Daphnia magna. Exposure to resorcinol by the use of peeling agents presents an acute exposure situation where the person is uncovered to a high focus 7. Acute effects have been described underneath these circumstances.<br />Complete restoration in all animals occurred within 1—1. Of the next research, the repeated-dose toxicity studies that were deemed to be most relevant to the danger evaluation are summarized in Appendix 6. In a study performed by NTP , 5 male and female F rats have been dosed with resorcinol in deionized water via gavage at 0, High-dose females had considerably decreased absolute and relative thymus weights. No other biologically important variations in organ weights have been noticed. In contrast to these findings, Eastin et al.<br /><br />There had been no published animal research displaying thyroidal results with a dose—response relationship that might be used for a tolerable intake. In the body of a full life cycle toxicity check OECD TG , Lima noticed no adverse results after forty eight h of publicity at the highest concentration tested, zero. Furthermore, Cronin et al. The fish and pond snails had been positioned instantly into the aquaria, while the remaining five species were segregated in several baskets and suspended within the aquaria. The only investigation into this finish-level is that from the dose range-discovering research reported in sections eight.<br />There isn't any guideline study on toxicity for aquatic plants out there. As just one concentration was examined, the study cannot be used in the danger analysis. There are a number of research available on acute toxicity to completely different fish species.<br />The bulk of the urine-recovered dye must have been taken up into the attractive layer of the pores and skin and then slowly released into the circulation. A cumulative four-day absorption assuming cm 2 of scalp was given as 0.<br />One issue increasing potential toxic effects is the application of resorcinol to injured pores and skin Cassano et al. Surviving F zero parental and F 1 following selection rats underwent full gross necropsy following the breeding interval seven F 0 males per group , following completion of weaning of F 1 pups F 0 females , following scheduled necropsy of F 0 females remaining seven F 0 males per group , on PND 28 F 1 exposed pups , or on PND 30 or 70 F 1 pups selected for behavioural testing.<br />Animals that died confirmed hyperaemia and distension of stomach and gut, while there have been no gross lesions at necropsy in survivors Flickinger, In one other research with CFY rats. Most of the research are of adequate high quality and acceptable for risk characterization functions.<br /><br /><h5></h5><br />Koppers Company studied possible skin irritating effects of flaked or industrial resorcinol in male albino rabbits mg beneath occlusive circumstances over 24 h, scoring after 24 and 72 h. In one study performed with male Syrian golden hamsters, which centered only on results on the forestomach, pyloric region, and urinary bladder, the animals had been dosed with 0 or 0.<br /><br /><h1></h1><br />More traditional-use circumstances would result in exposures of about 0. Further particulars weren't given.<br />Resorcinol is thought to form covalent bonds with haem Sessler et al. Effects on the thyroid gland have been reported both in animal research and in case-reviews in people. However, there are species variations in the susceptibility to goitrogens.<br /><br /><h2></h2><br />In another examine, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the study of Yeung et al.<br />These figures agree well with the above publicity estimate primarily based on the Yeung et al. |
Revision as of 01:21, 15 March 2020
In each species, there have been no adverse effects on final mean body weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions had been observed. In another study, rats were uncovered to zero or 0. No thyroid hormone measurements were performed.
Furthermore, chronic research with fish and Daphnia have been carried out. For the toxicity to aquatic vegetation, no guideline research is on the market. However, considering the available research for toxicity to aquatic plants, the NOEC for algae could be assumed to be greater than that for Daphnia magna. Exposure to resorcinol by the use of peeling agents presents an acute exposure situation where the person is uncovered to a high focus 7. Acute effects have been described underneath these circumstances.
Complete restoration in all animals occurred within 1—1. Of the next research, the repeated-dose toxicity studies that were deemed to be most relevant to the danger evaluation are summarized in Appendix 6. In a study performed by NTP , 5 male and female F rats have been dosed with resorcinol in deionized water via gavage at 0, High-dose females had considerably decreased absolute and relative thymus weights. No other biologically important variations in organ weights have been noticed. In contrast to these findings, Eastin et al.
There had been no published animal research displaying thyroidal results with a dose—response relationship that might be used for a tolerable intake. In the body of a full life cycle toxicity check OECD TG , Lima noticed no adverse results after forty eight h of publicity at the highest concentration tested, zero. Furthermore, Cronin et al. The fish and pond snails had been positioned instantly into the aquaria, while the remaining five species were segregated in several baskets and suspended within the aquaria. The only investigation into this finish-level is that from the dose range-discovering research reported in sections eight.
There isn't any guideline study on toxicity for aquatic plants out there. As just one concentration was examined, the study cannot be used in the danger analysis. There are a number of research available on acute toxicity to completely different fish species.
The bulk of the urine-recovered dye must have been taken up into the attractive layer of the pores and skin and then slowly released into the circulation. A cumulative four-day absorption assuming cm 2 of scalp was given as 0.
One issue increasing potential toxic effects is the application of resorcinol to injured pores and skin Cassano et al. Surviving F zero parental and F 1 following selection rats underwent full gross necropsy following the breeding interval seven F 0 males per group , following completion of weaning of F 1 pups F 0 females , following scheduled necropsy of F 0 females remaining seven F 0 males per group , on PND 28 F 1 exposed pups , or on PND 30 or 70 F 1 pups selected for behavioural testing.
Animals that died confirmed hyperaemia and distension of stomach and gut, while there have been no gross lesions at necropsy in survivors Flickinger, In one other research with CFY rats. Most of the research are of adequate high quality and acceptable for risk characterization functions.
Koppers Company studied possible skin irritating effects of flaked or industrial resorcinol in male albino rabbits mg beneath occlusive circumstances over 24 h, scoring after 24 and 72 h. In one study performed with male Syrian golden hamsters, which centered only on results on the forestomach, pyloric region, and urinary bladder, the animals had been dosed with 0 or 0.
More traditional-use circumstances would result in exposures of about 0. Further particulars weren't given.
Resorcinol is thought to form covalent bonds with haem Sessler et al. Effects on the thyroid gland have been reported both in animal research and in case-reviews in people. However, there are species variations in the susceptibility to goitrogens.
In another examine, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the study of Yeung et al.
These figures agree well with the above publicity estimate primarily based on the Yeung et al.